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Blue Light from Dental Resin Curing Unit Causes Light-Induced Vasoconstriction in Isolated Rat Aorta 歯科用レジン照射器による青色光は摘出ラット大動脈に対して光誘導性血管収縮を誘導す 岩田, 将 イワタ, ショウ Iwata, Sho open access Reactive oxygen species Dental curing lights Vasoconstriction Antioxidant 2015 application/pdf Aims: Currently, the blue light of resin curing unit is frequently used in dental treatment. However, the influence of the blue light irradiation on oral tissue is not lear. The aim of this study was to elucidate the effect of dental blue light irradiation on vascular smooth muscle. Methods: Isolated rat descending aorta was suspended in a superfusion chamber nd superfused continuously with Krebs-Ringer solution. The changes in isometric orce of blue light irradiation were assessed using vessel strips superfused with the Krebs-Ringer solution alone or the Krebs-Ringer solutions containing 10 µM hentolamine, 100 mM dimethyl sulfoxide, 10 unit/mL superoxide dismutase, or 5 M L-histidine. The reactive oxygen species (ROS) scavenging activity of antioxidants was examined using the electron spin resonance technique espectively. Results: We first demonstrated that the vasoconstriction was induced by irradiated of blue light using dental resin curing unit. The vasoconstriction was inhibited by ncluding in the Krebs-Ringer solution an α-receptor blocker that inhibits the eurotransmitter. This phenomenon was controlled with the addition of ROS cavengers. Conclusions: Blue light irradiation of multiple times in dental treatment might have the potential to accelerate aging of pulpal blood vessel from ischemia through dental pulp vasoconstriction via ROS generation. In addition, prolonged and/or repeated blue light irradiation could cause ROS-induced oxidative stress such as ischemia-reperfusion injury on pulpal blood vessel. Therefore, preintake of ntioxidants is suggested to avoid effects such as aging of dental pulp due to blue light irradiation-induced ROS in dental clinic treatments. eng doctoral thesis VoR https://kdu.repo.nii.ac.jp/records/945 Oral Health and Dental Management, 13(4):1147-1151, 2014. doi: 10.4172/2247-2452.1000745 https://www.omicsonline.org/archive/ohdm-volume-13-issue-4-year-2014.html OMICS 甲第479号 博士（臨床歯学） 2016-03-17 32703 神奈川歯科大学 https://kdu.repo.nii.ac.jp/record/945/files/kou479_fulltext.pdf application/pdf 987.7 kB 2021-03-24 https://kdu.repo.nii.ac.jp/record/945/files/kou479_summary.pdf application/pdf 243.0 kB 2016-07-05 https://kdu.repo.nii.ac.jp/record/945/files/kou479_thesisreview.pdf application/pdf 193.4 kB 2016-07-05