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電子スピン共鳴(ESR)法とXYZ化学発光法による鶏血藤の活性酸素消去活性の評価 Reactive oxygen species scavenging activity of Jixueteng evaluated by electron spin resonance (ESR) and photon emission 髙道, 麻臣 90 タカミチ, マオミ Takamichi, Maomi 91 Antioxidants Drugs, Chinese Herbal Electron Spin Resonance Spectroscopy Luminescent Measurements Photons Reactive Oxygen Species 神奈川歯科大学 博士（臨床歯学） 2014 application/pdf Jixueteng, the dried stem of Spatholobus suberectus Dunn (Leguminosae), is a traditional Chinese herbal medicine that is commonly classified as a herb that promotes blood circulation and can be used to treat blood stasis. The aim of this study was to examine the reactive oxygen species (ROS) scavenging activity of Jixueteng and other herbal medicines. The ROS scavenging activities of the water extracts of Jixueteng, Cnidium officinale and Salvia miltiorrhiza were examined using an electron spin resonance (ESR) technique and faint luminescence measurement. The ESR signal intensities of the superoxide anion (O2·) and hydroxyl radical (HO·) were reduced more by Jixueteng than the other herbal medicines we tested. High photon emission intensity to hydrogen peroxide (H202) and HO· was observed in Jixueteng using the XYZ chemiluminescence system that was used as faint luminescence measurement and analysis. The results of the present study revealed that the ROS scavenging activity of 8% Jixueteng was the strongest among the herbal medicines we tested. It has been reported that Jixueteng includes various polyphenols. In the ROS scavenging activity by Jixueteng, it is supposed that the antioxidant activity caused by these polyphenols would contribute greatly. In conclusion, a water extract component of Jixueteng had potent free radical scavenging activity and an antioxidative effect that inhibited the oxidative actions of O2·⁻, H2O2 and HO·. Therefore, Jixueteng represents a promising therapeutic drug for reactive oxygen-associated pathologies. doctoral thesis 2015-03-17 VoR application/pdf application/pdf application/pdf 甲第459号 https://kdu.repo.nii.ac.jp/record/27/files/kou459_fulltext.pdf https://kdu.repo.nii.ac.jp/record/27/files/kou459_summary.pdf https://kdu.repo.nii.ac.jp/record/27/files/kou459_thesisreview.pdf https://kdu.repo.nii.ac.jp/records/27 eng Natural Product Communications, 9(12):1755-1759, 2014 This manuscript is final version prepared by the author(s), not the PDF file of the paper published in the Online Journal. Natural Product Communications (ISSN 1934-578X (printed); 1555-9475 (online)) The copyright of this paper belongs to the Natural Product Incorporation. ©2005 Natural Product Incorporation open access