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新生ラットの単離脳幹脊髄標本を用いたセボフルラン、プロポフォール、レミフェンタニルによる呼吸抑制に対するオレキシンＢによる拮抗作用について Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats 梅澤, 伸夫 2558 ウメザワ, ノブオ Umezawa, Nobuo 2559 Anesthetics Animals Animals, Newborn Brain Stem Disease Models, Animal Intracellular Signaling Peptides and Proteins Methyl Ethers Neuropeptides Orexins Piperidines Propofol Rats Rats, Wistar Respiratory Insufficiency Spinal Cord 神奈川歯科大学 博士（歯学） 2015 application/pdf Orexins (hypocretins) play a crucial role in arousal, feeding, and endocrine function. We previously reported that orexin-B activated respiratory neurons in the isolated brainstem-spinal cords of neonatal rats. We herein determined whether orexin-B antagonized respiratory depression induced by sevoflurane, propofol, or remifentanil. We recorded C4 nerve bursts as an index of inspiratory activity in a brainstem-spinal cord preparation. The preparation was superfused with a solution equilibrated with 3% sevoflurane alone for 10 min and the superfusate was then switched to a solution containing sevoflurane plus orexin-B. Sevoflurane decreased the C4 burst rate and the integrated C4 amplitude. The C4 burst rate and amplitude were reversed by 0.5 μM orexin-B, but not by 0.1 μM orexin-B. The decrease induced in the C4 burst rate by 10 μM propofol or 0.01 μM remifentanil was significantly antagonized by 0.1 μM orexin-B. Respiratory depression induced by a higher concentration (0.1 μM) of remifentanil was not restored by 0.1 μM orexin-B. These results demonstrated that orexin-B antagonized respiratory depression induced by sevoflurane, propofol, or remifentanil. doctoral thesis 2016-03-17 VoR application/pdf application/pdf application/pdf 甲第484号 https://kdu.repo.nii.ac.jp/record/950/files/kou484_fulltext.pdf https://kdu.repo.nii.ac.jp/record/950/files/kou484_summary.pdf https://kdu.repo.nii.ac.jp/record/950/files/kou484_thesisreview.pdf https://kdu.repo.nii.ac.jp/records/950 eng Respiratory Physiology & Neurobiology, 205:61-65, 2015. doi: 10.1016/j.resp.2014.10.013 Elsevier https://doi.org/10.1016/j.resp.2014.10.013 open access