{"created":"2023-06-20T15:01:30.164413+00:00","id":1049,"links":{},"metadata":{"_buckets":{"deposit":"9e91c670-83a9-476b-b93a-9ae338219e00"},"_deposit":{"created_by":10,"id":"1049","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1049"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00001049","sets":["77:80:88"]},"author_link":["2942","2943","2944","2945","2946","2947","2948","2949","2950","2951","2952","2587"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"38","bibliographicPageStart":"34","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"神奈川歯学","bibliographic_titleLang":"ja"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"β-TCP骨補填材顆粒近傍での骨形成に対するコラーゲン由来トリペプチド経口投与の影響について検討した。ウィスター系ラットを使用し、頭蓋冠に歯科用トレフィンバーを用いて、脳硬膜に達しないように骨欠損を形成した。コラーゲンペプチドの基本ユニットGly-X-Yを20%程度含むコラーゲン由来トリペプチド(Ctp)を作製した。Ctpの経口摂取によって、骨欠損部に埋入された骨補填材の周囲にも、新生骨の形成が促された。Ctp投与群においては、骨形成が既存骨近傍だけでなく、骨補填材の周囲でも早期に進行するという様子が認められた。経口投与されたCtpが速やかに体内に吸収されること、およびCtpが骨芽細胞の成熟を促すOsterixの発現を促して細胞のコラーゲン合成および石灰化を促進すること、骨折モデルラットに経口投与した場合には骨折の治癒を促すことなどが明らかにされており、Ctpの経口投与の有効性が示唆された。","subitem_description_type":"Abstract"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18924/00001027","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"神奈川歯科大学学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00043576","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0454-8302","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古澤, 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常男","creatorNameLang":"ja"},{"creatorName":"タカハシ, ツネオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Toshitake","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okudera, Toshimitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Yasuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsushima, Yuta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Unuma, Hidero","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, 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