{"created":"2023-06-20T15:01:37.121994+00:00","id":1173,"links":{},"metadata":{"_buckets":{"deposit":"8f802908-a628-49c4-8b0e-21e5dccf9d09"},"_deposit":{"created_by":10,"id":"1173","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"1173"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00001173","sets":["77:105:107"]},"author_link":["3567","3566","3571","3570","3568","3563","3569","3564","3554","3562","3565"],"item_10001_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"多菌種バイオフィルムモデルにて示された、第四級アンモニウム塩を含有する新規シランカップリング剤の抗菌活性","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"55","bibliographicPageStart":"54","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"神奈川歯学","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Journal of the Kanagawa Odontological Society","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"新規な第四級アンモニウムシランカップリング剤であるヨウ化N-アリル-N-デシル-N-メチル-N-トリメトキシシリルプロピルアンモニウム(10-I)が多菌種バイオフィルムモデルに対して発揮する抗菌活性を調べる実験を施行した。上記モデルにおけるバイオフィルム形成初期を実験系に用いることで、口腔内プラーク様のバイオフィルムが固相表面に形成される状況を模倣させた。カバーグラスを濃度800ppmの10-I溶液に1時間浸漬して表面修飾処理を行い、上記のバイオフィルムを形成させた。コロニー形成単位(CFU)を計数した結果、10-I処理を行った群では対照群に対してCFUが80%減少したことから、10-Iが強い抗菌活性を有することが実証された。10-Iによる表面修飾処理は、常在菌に関連する歯科疾患のみならず誤嚥性肺炎などの全身合併症を予防低減する効果的な方法となることが当結果から示唆された。","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"新規な第四級アンモニウムシランカップリング剤であるヨウ化N-アリル-N-デシル-N-メチル-N-トリメトキシシリルプロピルアンモニウム(10-I)が多菌種バイオフィルムモデルに対して発揮する抗菌活性を調べる実験を施行した。上記モデルにおけるバイオフィルム形成初期を実験系に用いることで、口腔内プラーク様のバイオフィルムが固相表面に形成される状況を模倣させた。カバーグラスを濃度800ppmの10-I溶液に1時間浸漬して表面修飾処理を行い、上記のバイオフィルムを形成させた。コロニー形成単位(CFU)を計数した結果、10-I処理を行った群では対照群に対してCFUが80%減少したことから、10-Iが強い抗菌活性を有することが実証された。10-Iによる表面修飾処理は、常在菌に関連する歯科疾患のみならず誤嚥性肺炎などの全身合併症を予防低減する効果的な方法となることが当結果から示唆された。","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18924/00001135","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"神奈川歯科大学学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00043576","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0454-8302","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Miyake-Aoki, 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