{"created":"2023-06-20T15:00:18.999760+00:00","id":27,"links":{},"metadata":{"_buckets":{"deposit":"db1245cb-b7c8-4618-9b7e-e95c4660ea90"},"_deposit":{"created_by":10,"id":"27","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"27"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00000027","sets":["6:8"]},"author_link":["90","91"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"電子スピン共鳴(ESR)法とXYZ化学発光法による鶏血藤の活性酸素消去活性の評価","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-17"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"神奈川歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"32703","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（臨床歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2014","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Jixueteng, the dried stem of Spatholobus suberectus Dunn (Leguminosae), is a traditional Chinese herbal medicine that is commonly classified as a herb that promotes blood circulation and can be used to treat blood stasis. The aim of this study was to examine the reactive oxygen species (ROS) scavenging activity of Jixueteng and other herbal medicines. The ROS scavenging activities of the water extracts of Jixueteng, Cnidium officinale and Salvia miltiorrhiza were examined using an electron spin resonance (ESR) technique and faint luminescence measurement. The ESR signal intensities of the superoxide anion (O2·) and hydroxyl radical (HO·) were reduced more by Jixueteng than the other herbal medicines we tested. High photon emission intensity to hydrogen peroxide (H202) and HO· was observed in Jixueteng using the XYZ chemiluminescence system that was used as faint luminescence measurement and analysis. The results of the present study revealed that the ROS scavenging activity of 8% Jixueteng was the strongest among the herbal medicines we tested. It has been reported that Jixueteng includes various polyphenols. In the ROS scavenging activity by Jixueteng, it is supposed that the antioxidant activity caused by these polyphenols would contribute greatly. In conclusion, a water extract component of Jixueteng had potent free radical scavenging activity and an antioxidative effect that inhibited the oxidative actions of O2·⁻, H2O2 and HO·. Therefore, Jixueteng represents a promising therapeutic drug for reactive oxygen-associated pathologies.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第459号"}]},"item_10006_heading_21":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_headline":"PDF/A","subitem_heading_language":"ja"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Natural Product Communications, 9(12):1755-1759, 2014"}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This manuscript is final version prepared by the author(s), not the PDF file of the paper published in the Online Journal. Natural Product Communications (ISSN 1934-578X (printed); 1555-9475 (online))    The copyright of this paper belongs to the Natural Product Incorporation. ©2005 Natural Product Incorporation"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"髙道, 麻臣","creatorNameLang":"ja"},{"creatorName":"タカミチ, マオミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"90","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamichi, Maomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"91","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-14"}],"displaytype":"detail","filename":"kou459_fulltext.pdf","filesize":[{"value":"700.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Full Text（全文）","objectType":"fulltext","url":"https://kdu.repo.nii.ac.jp/record/27/files/kou459_fulltext.pdf"},"version_id":"3d64b6c3-04ae-4c1b-9824-fc24b25f47c8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-14"}],"displaytype":"detail","filename":"kou459_summary.pdf","filesize":[{"value":"176.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨","url":"https://kdu.repo.nii.ac.jp/record/27/files/kou459_summary.pdf"},"version_id":"33d364ad-30a4-4902-968c-883536e96bc8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-14"}],"displaytype":"detail","filename":"kou459_thesisreview.pdf","filesize":[{"value":"193.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文審査要旨、最終審査の結果の要旨","url":"https://kdu.repo.nii.ac.jp/record/27/files/kou459_thesisreview.pdf"},"version_id":"dda41d5e-3c26-43c7-8110-7acdd084e137"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antioxidants","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drugs, Chinese Herbal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Electron Spin Resonance Spectroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Luminescent Measurements","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Photons","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Reactive Oxygen Species","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Reactive oxygen species scavenging activity of Jixueteng evaluated by electron spin resonance (ESR) and photon emission","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reactive oxygen species scavenging activity of Jixueteng evaluated by electron spin resonance (ESR) and photon emission","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"10","path":["8"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-14"},"publish_date":"2016-04-14","publish_status":"0","recid":"27","relation_version_is_last":true,"title":["Reactive oxygen species scavenging activity of Jixueteng evaluated by electron spin resonance (ESR) and photon emission"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-12-21T01:24:31.370437+00:00"}