{"created":"2023-06-20T15:01:21.888602+00:00","id":903,"links":{},"metadata":{"_buckets":{"deposit":"4c286a5f-648a-48ae-a897-ba908431e402"},"_deposit":{"created_by":10,"id":"903","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"903"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00000903","sets":["6:9"]},"author_link":["2371","2459"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-17"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"神奈川歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"32703","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、セボフルランによるプレコンディショニングやポストコンディショニングが心筋虚血再灌流後の心筋梗塞サイズを減少させることが明らかにされている。しかしセボフルランによるプレコンディショニングとポストコンディショニングを併用した場合の心筋保護効果がさらに増強するか否かは十分に検討がなされていない。本研究では、in vivoウサギ心筋虚血再灌流モデルを用い、セボフルランによるプレコンディショニングおよびポストコンディショニングが心筋虚血再灌流障害に及ぼす影響を、循環動態、心筋梗塞サイズ、および再灌流不整脈の発生率を指標として検討した。その結果、心筋梗塞サイズは薬物を投与しない群に対し、プレコンディショニング群、ポストコンディショニング群、プレコンディショニングとポストコンディショニングの併用群のすべてにおいて有意に減少した。しかし両者の効果に相加作用は認められなかった。またポストコンディショニング群およびプレコンディショニングとポストコンディショニングの併用群で再灌流不整脈の発生が抑制された。以上の結果より、プレコンディショニングとポストコンディショニングの併用で心筋壊死縮小効果に相加作用は認められなかった。またプレコンディショニングでは再灌流不整脈の発生を抑制することはなかったが、ポストコンディショニングで再灌流直後にセボフルランを短時間曝露すれば再灌流不整脈の発生が抑制されることが示唆された。(著者抄録)","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第440号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"日本歯科麻酔学会雑誌, 42(2):196-203, 2014"}]}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"板倉, 紹子","creatorNameLang":"ja"},{"creatorName":"イタクラ, ショウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itakura, Shoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2459","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-26"}],"displaytype":"detail","filename":"kou440_fulltext.pdf","filesize":[{"value":"971.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Full Text（全文）","objectType":"fulltext","url":"https://kdu.repo.nii.ac.jp/record/903/files/kou440_fulltext.pdf"},"version_id":"9ae0baca-a409-4859-a0d3-9eea99a35909"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-26"}],"displaytype":"detail","filename":"kou440_summary.pdf","filesize":[{"value":"110.5 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kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文審査要旨、最終審査の結果の要旨","url":"https://kdu.repo.nii.ac.jp/record/903/files/kou440_thesisreview.pdf"},"version_id":"19d9b86c-db67-4a18-9055-e5d8344f9401"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血圧","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患モデル(動物)","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋梗塞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋再灌流","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"*心筋再灌流傷害(実験的)","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"心拍数","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"不整脈","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"分散分析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"*心筋虚血プレコンディショニング","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"*Sevoflurane(薬理学)","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"*虚血ポストコンディショニング","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Rate-Pressure Product","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ウサギ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"オス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral 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