{"created":"2023-06-20T15:01:22.711085+00:00","id":916,"links":{},"metadata":{"_buckets":{"deposit":"0f133fea-65cd-4152-9e19-f77fe3185b38"},"_deposit":{"created_by":10,"id":"916","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"916"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00000916","sets":["6:9"]},"author_link":["2399","2400"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"全身麻酔下家兎を用いたブプレノルフィンによる中枢性呼吸抑制に対するドネペジルによる拮抗作用","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-17"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"神奈川歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"32703","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Buprenorphine is a mixed opioid receptor agonist-antagonist used in acute and chronic pain management. Although this agent's analgesic effect increases in a dose-dependent manner, buprenorphine-induced respiratory depression shows a marked ceiling effect at higher doses, which is considered to be an indicator of safety. Nevertheless, cases of overdose mortality or severe respiratory depression associated with buprenorphine use have been reported. Naloxone can reverse buprenorphine-induced respiratory depression, but is slow-acting and unstable, meaning that new drug candidates able to specifically antagonize buprenorphine-induced respiratory depression are needed in order to enable maximal analgesic effect without respiratory depression. Acetylcholine is an excitatory neurotransmitter in central respiratory control. We previously showed that a long-acting acetylcholinesterase inhibitor, donepezil, antagonizes morphine-induced respiratory depression. We have now investigated how donepezil affects buprenorphine-induced respiratory depression in anesthetized, paralyzed, and artificially ventilated rabbits. We measured phrenic nerve discharge as an Index of respiratory rate and amplitude, and compared discharges following the injection of buprenorphine with discharges following the injection of donepezil. Buprenorphine-induced suppression of the respiratory rate and respiratory amplitude was antagonized by donepezil (78.4 +/- 4.8 %, 92.3% +/- 22.8 % of control, respectively). These findings indicate that systemically administered donepezil restores buprenorphine-induced respiratory depression in anesthetized rabbits.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第490号"}]},"item_10006_heading_21":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_headline":"PDF/A","subitem_heading_language":"ja"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Biological Research, 42(4):469-475, 2009"}]}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Biological Research"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"櫻庭, 茂樹","creatorNameLang":"ja"},{"creatorName":"サクラバ, シゲキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakuraba, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2400","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-27"}],"displaytype":"detail","filename":"otsu490_fulltext.pdf","filesize":[{"value":"726.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Full Text（全文）","objectType":"fulltext","url":"https://kdu.repo.nii.ac.jp/record/916/files/otsu490_fulltext.pdf"},"version_id":"461a9f8e-a328-45cf-ada5-169d07e7848c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-27"}],"displaytype":"detail","filename":"otsu491_summary.pdf","filesize":[{"value":"212.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨","url":"https://kdu.repo.nii.ac.jp/record/916/files/otsu491_summary.pdf"},"version_id":"367fac45-fced-411b-a882-d3b3c9b140c1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-27"}],"displaytype":"detail","filename":"otsu491_thesisreview.pdf","filesize":[{"value":"156.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文審査要旨、最終審査の結果の要旨","url":"https://kdu.repo.nii.ac.jp/record/916/files/otsu491_thesisreview.pdf"},"version_id":"dcc1cfa5-9768-40dd-a6a4-d093ce0e3399"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Buprenorphine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholinesterase Inhibitors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Indans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Narcotic Antagonists","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phrenic Nerve","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Piperidines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rabbits","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Respiratory Insufficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"10","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-27"},"publish_date":"2016-04-27","publish_status":"0","recid":"916","relation_version_is_last":true,"title":["Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-12-21T01:26:18.702100+00:00"}