{"created":"2023-06-20T15:01:22.785042+00:00","id":917,"links":{},"metadata":{"_buckets":{"deposit":"fb67b0fc-10bc-45fb-9911-d6109df31fe9"},"_deposit":{"created_by":10,"id":"917","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"917"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00000917","sets":["6:9"]},"author_link":["2406","2466"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-17"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"神奈川歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"32703","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"P.gingivalisジンジパインIgY抗体(IgY-GP)のラット実験歯周炎に対する歯槽骨吸収抑制効果について検討した。P.gingivalis感染実験は、3週齢のSD系SPFラットを用いた。IgY-GPは、P.gingivalisの増殖に対する抑制効果を認め、培養上清中のトリプシン様活性を抑制した。IgY-GP添加により、P.gingivalis菌体の凝集塊を確認した。IgY-GP添加によるP.gingivalisの凝集に伴って、ヒト歯肉上皮細胞への付着率が高まった。IgY-GPをラット口腔へ投与することにより、P.gingivalis感染による歯槽骨吸収の抑制効果を確認した。P.gingivalisの産生するジンジパインに対する鶏卵抗体は、歯周病に有用な受動免疫療法になり得ることが示唆された。","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第491号"}]},"item_10006_heading_21":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_headline":"PDF/A","subitem_heading_language":"ja"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"神奈川歯学, 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