{"created":"2023-06-20T15:01:22.859283+00:00","id":918,"links":{},"metadata":{"_buckets":{"deposit":"c44b5781-e151-4af1-b261-7029e4a9f4c2"},"_deposit":{"created_by":10,"id":"918","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"918"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00000918","sets":["6:9"]},"author_link":["2407","2408"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Pycnogenol®の歯槽骨吸収および破骨細胞分化誘導に対する抑制効果の検討","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-17"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"神奈川歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"32703","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2013","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pycnogenol(®) (PYC) is a standardized bark extract from French maritime pine (Pinus pinaster Aiton). We examined the inhibitory effects of PYC on alveolar bone resorption, which is a characteristic feature of periodontitis, induced by Porphyromonas gingivalis (P. gingivalis) and osteoclast differentiation. In rat periodontitis model, rats were divided into four groups: group A served as the non-infected control, group B was infected orally with P. gingivalis ATCC 33277, group C was administered PYC in the diet (0.025%: w/w), and group D was infected with P. gingivalis and administered PYC. Administration of PYC along with P. gingivalis infection significantly reduced alveolar bone resorption. Treatment of P. gingivalis with 1 µg/ml PYC reduced the number of viable bacterial cells. Addition of PYC to epithelial cells inhibited adhesion and invasion by P. gingivalis. The effect of PYC on osteoclast formation was confirmed by tartrate-resistant acid phosphatase staining. PYC treatment significantly inhibited osteoclast formation. Addition of PYC (1-100 µg/ml) to purified osteoclasts culture induced cell apoptosis. These results suggest that PYC may prevent alveolar bone resorption through its antibacterial activity against P. gingivalis and by suppressing osteoclastogenesis. Therefore, PYC may be useful as a therapeutic and preventative agent for bone diseases such as periodontitis.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第492号"}]},"item_10006_heading_21":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_headline":"PDF/A","subitem_heading_language":"ja"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Phytotherapy Research, 29(2):251-259, 2015"}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Wiley"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://onlinelibrary.wiley.com/doi/10.1002/ptr.5245/abstract;jsessionid=BC60939A7ACF6BD8B9010A4456471F2F.f02t04","subitem_relation_type_select":"URI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉本, 秀樹","creatorNameLang":"ja"},{"creatorName":"スギモト, ヒデキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugimoto, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2408","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-27"}],"displaytype":"detail","filename":"otsu492_fulltext.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Full Text（全文）","objectType":"fulltext","url":"https://kdu.repo.nii.ac.jp/record/918/files/otsu492_fulltext.pdf"},"version_id":"09a053d5-9341-41fe-b42a-fda4b8ae8cc9"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-27"}],"displaytype":"detail","filename":"otsu492_summary.pdf","filesize":[{"value":"217.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨","url":"https://kdu.repo.nii.ac.jp/record/918/files/otsu492_summary.pdf"},"version_id":"d17da2c8-452d-47f3-af83-6509448d5b0c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-27"}],"displaytype":"detail","filename":"otsu492_thesisreview.pdf","filesize":[{"value":"238.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文審査要旨、最終審査の結果の要旨","url":"https://kdu.repo.nii.ac.jp/record/918/files/otsu492_thesisreview.pdf"},"version_id":"7b84ebef-c242-4bd8-9dd8-705183000f77"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Acid Phosphatase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alveolar Bone Loss","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-Bacterial Agents","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone and Bones","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Line","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cells, Cultured","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epithelial Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Flavonoids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gingiva","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Isoenzymes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Inbred BALB C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoclasts","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Periodontitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pinus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plant Bark","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Porphyromonas gingivalis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats, Sprague-Dawley","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Inhibitory effects of French pine bark extract, Pycnogenol®, on alveolar bone resorption and on the osteoclast differentiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitory effects of French pine bark extract, Pycnogenol®, on alveolar bone resorption and on the osteoclast differentiation.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"10","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-27"},"publish_date":"2016-04-27","publish_status":"0","recid":"918","relation_version_is_last":true,"title":["Inhibitory effects of French pine bark extract, Pycnogenol®, on alveolar bone resorption and on the osteoclast differentiation."],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-12-21T01:26:23.827780+00:00"}