{"created":"2023-06-20T15:01:24.113694+00:00","id":948,"links":{},"metadata":{"_buckets":{"deposit":"0bff0193-5627-462f-a915-80c89b5caa2c"},"_deposit":{"created_by":10,"id":"948","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"948"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00000948","sets":["6:7"]},"author_link":["2534","2535"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ラット歯肉における局所虚血／再灌流誘発性反応性充血の抑制に対する(6R)-5,6,7,8-tetrahydro-L-biopterinの防御効果","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-17"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"神奈川歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"32703","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（臨床歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2015","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We herein investigated the regulatory mechanism in the circulation responsible for rat gingival reactive hyperemia (RH) associated with ischemia/reperfusion (I/R). RH was analyzed using a laser Doppler flowmeter. RH and I/R were elicited by gingival compression and release with a laser Doppler probe. RH increased in a time-dependent manner when the duration of compression was between 30 s and 20 min. This increase was significantly suppressed by N (ω)-nitro-l-arginine-methyl-ester (l-NAME), 7-nitroindazole (7-NI), and 2,4-diamino-6-hydroxypyrimidine (DAHP). However, RH was markedly inhibited following 60 min of compression. This inhibition was significantly decreased by treatments with superoxide dismutase (SOD), (6R)-5,6,7,8-tetrahydro-l-biopterin (BH4), and sepiapterin. The luminescent intensity of superoxide anion (O2 (•-))-induced 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo-[1,2-a] pyrazine-3-one (MCLA) was markedly decreased by SOD and BH4, but only slightly by sepiapterin. BH4 significantly decreased O2 (•-) scavenging activity in a time-dependent manner. These results suggested that nitric oxide (NO) secreted by the nitrergic nerve played a role in regulating local circulation in rat gingiva. This NO-related regulation of local circulation was temporarily inhibited in the gingiva by the I/R treatment. The decrease observed in the production of NO, which was caused by suppression of NO synthase (NOS) activity subsequent to depletion of the NOS co-factor BH4 by O2 (•-), played a partial role in this inhibition.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第482号"}]},"item_10006_heading_21":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_headline":"※セキュリティ設定あり","subitem_heading_language":"ja"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Clinical Biochemistry and Nutrition, 58(1):69-75, 2016.1. doi: 10.3164/jcbn.15-69"}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"J-STAGE"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/jcbn/58/1/58_15-69/_article","subitem_relation_type_select":"URI"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本酸化ストレス学会"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 優作","creatorNameLang":"ja"},{"creatorName":"タナカ, ユウサク","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Yusaku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2535","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-20"}],"displaytype":"detail","filename":"kou482_fulltext.pdf","filesize":[{"value":"784.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Full Text（全文）","objectType":"fulltext","url":"https://kdu.repo.nii.ac.jp/record/948/files/kou482_fulltext.pdf"},"version_id":"306281ff-3d4a-487d-8b36-9d6ed362d46e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-06"}],"displaytype":"detail","filename":"kou482_summary.pdf","filesize":[{"value":"183.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨","url":"https://kdu.repo.nii.ac.jp/record/948/files/kou482_summary.pdf"},"version_id":"426b5bb2-563c-4b74-81b3-6d1e1ba5d1b5"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-06"}],"displaytype":"detail","filename":"kou482_thesisreview.pdf","filesize":[{"value":"270.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文審査要旨、最終審査の結果の要旨","url":"https://kdu.repo.nii.ac.jp/record/948/files/kou482_thesisreview.pdf"},"version_id":"b3da8baa-8422-4615-9117-9c5dcb57f4cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BH4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gingiva","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitric oxide synthases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive hyperemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reperfusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"10","path":["7"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-07-06"},"publish_date":"2016-07-06","publish_status":"0","recid":"948","relation_version_is_last":true,"title":["Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-12-21T01:26:51.273818+00:00"}