{"created":"2023-06-20T15:01:24.262527+00:00","id":950,"links":{},"metadata":{"_buckets":{"deposit":"8c370c3b-e75d-477d-b70b-43616491a241"},"_deposit":{"created_by":10,"id":"950","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"950"},"status":"published"},"_oai":{"id":"oai:kdu.repo.nii.ac.jp:00000950","sets":["6:7"]},"author_link":["2558","2559"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"新生ラットの単離脳幹脊髄標本を用いたセボフルラン、プロポフォール、レミフェンタニルによる呼吸抑制に対するオレキシンＢによる拮抗作用について","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-17"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"神奈川歯科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"32703","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2015","subitem_description_type":"Other"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Orexins (hypocretins) play a crucial role in arousal, feeding, and endocrine function. We previously reported that orexin-B activated respiratory neurons in the isolated brainstem-spinal cords of neonatal rats. We herein determined whether orexin-B antagonized respiratory depression induced by sevoflurane, propofol, or remifentanil. We recorded C4 nerve bursts as an index of inspiratory activity in a brainstem-spinal cord preparation. The preparation was superfused with a solution equilibrated with 3% sevoflurane alone for 10 min and the superfusate was then switched to a solution containing sevoflurane plus orexin-B. Sevoflurane decreased the C4 burst rate and the integrated C4 amplitude. The C4 burst rate and amplitude were reversed by 0.5 μM orexin-B, but not by 0.1 μM orexin-B. The decrease induced in the C4 burst rate by 10 μM propofol or 0.01 μM remifentanil was significantly antagonized by 0.1 μM orexin-B. Respiratory depression induced by a higher concentration (0.1 μM) of remifentanil was not restored by 0.1 μM orexin-B. These results demonstrated that orexin-B antagonized respiratory depression induced by sevoflurane, propofol, or remifentanil.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第484号"}]},"item_10006_heading_21":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_headline":"PDF/A","subitem_heading_language":"ja"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Respiratory Physiology & Neurobiology, 205:61-65, 2015. doi: 10.1016/j.resp.2014.10.013"}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Elsevier"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.resp.2014.10.013","subitem_relation_type_select":"DOI"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梅澤, 伸夫","creatorNameLang":"ja"},{"creatorName":"ウメザワ, ノブオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Umezawa, Nobuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2559","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-02"}],"displaytype":"detail","filename":"kou484_fulltext.pdf","filesize":[{"value":"496.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Full Text（全文）","objectType":"fulltext","url":"https://kdu.repo.nii.ac.jp/record/950/files/kou484_fulltext.pdf"},"version_id":"2a1d9212-377f-4797-9c67-f0b2197526d6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-06"}],"displaytype":"detail","filename":"kou484_summary.pdf","filesize":[{"value":"141.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文内容要旨","url":"https://kdu.repo.nii.ac.jp/record/950/files/kou484_summary.pdf"},"version_id":"ca7923e9-8fa9-4733-8317-909b2c5d0b9f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-06"}],"displaytype":"detail","filename":"kou484_thesisreview.pdf","filesize":[{"value":"241.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"論文審査要旨、最終審査の結果の要旨","url":"https://kdu.repo.nii.ac.jp/record/950/files/kou484_thesisreview.pdf"},"version_id":"56cefb5c-69d3-46ff-b5d8-20e2a081efcb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anesthetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animals, Newborn","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Brain Stem","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Disease Models, Animal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intracellular Signaling Peptides and Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Methyl Ethers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuropeptides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Orexins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Piperidines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Propofol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats, Wistar","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Respiratory Insufficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spinal Cord","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"10","path":["7"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-07-06"},"publish_date":"2016-07-06","publish_status":"0","recid":"950","relation_version_is_last":true,"title":["Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-12-21T01:26:56.017389+00:00"}