@phdthesis{oai:kdu.repo.nii.ac.jp:00000966,
 author = {一瀬, 昭太 and ICHINOSE, Shota},
 month = {2016-10-20, 2016-07-07, 2016-07-07},
 note = {2015, application/pdf, 嚥下体操は摂食嚥下機能の維持，促進のため，多くの介護施設において行われている．嚥下体操による唾液中の活性酸素種（ROS）消去能の変動を明らかにし，嚥下体操における抗酸化システムを評価することによって，嚥下体操の有用性を検討したので報告する．対象：研究に同意が得られた者で，反復唾液嚥下テストが30秒間に3回以上であり，日常において嚥下体操を行っていない男性23名，女性26名（平均年齢47.2±25.5歳）とした．70歳以上80歳未満の対象者はいないため，A群：20歳以上50歳未満，B群：50歳以上70歳未満，C群：80歳以上の３群に分けて検討した．方法：合併疾患などの情報を収集し，嚥下体操前後の安静時唾液を採取した．唾液分泌量の測定およびelectron spin resonance（ESR）法による唾液中ROS消去能の測定を行い，嚥下体操前，後におけるROS消去能の相違，各群における嚥下体操前後での変動について比較検討した．結果：唾液分泌量は，嚥下体操前，後ともにC群で減少傾向にあったが，個人差が大きく，有意な差を認めなかった．C群でA，B群に比較して，嚥下体操前のFe2＋/H2O2系におけるHO•およびO2•−に対する唾液中の抗酸化能が有意に高値を示した．嚥下体操前後の比較では，唾液中のHO•消去能はA群では有意な上昇を認めたが，B，C群では有意差を認めなかった．以上の結果から，C群で嚥下体操前のO2•−消去能が高値を示したことは，加齢や合併疾患の影響による酸化ストレスの亢進に対する抗酸化活性を示す適応反応がみられた可能性が考えられた．A群でHO•消去能が上昇したことは，嚥下体操を行うことで唾液中の抗酸化力を高めたことから，口腔内の抗酸化システムにおける防御機構が有益に作用する可能性も考えられた．しかしながら，B，C群においては有意な差がなかったことから，今回行った１回の嚥下体操では口腔内の抗酸化活性に効果がみられなかった．今後はこのような対象群の抗酸化活性を上昇させる嚥下機能や口腔機能の維持，向上に関連した体操の検討および継続した嚥下体操における抗酸化活性の評価を行いたい．, It is well known in many nursing homes that swallowing exercises promote the maintenance of swallowing function. Using swallowing exercises, we evaluated the antioxidant activity of saliva against reactive oxygen species such as HO and O2•−, in individuals from different generations.Subjects：Individuals who provided informed consent, had normal levels of repetitive saliva swallowing, and did not perform swallowing exercises every day were eligible for this study. The following groups were investigated separately：group A：subjects aged 20-49 years；group B：subjects aged 50-70 years；group C：subjects aged 80 years and over.Method：After collecting general information such as any possible complicating factors, resting saliva was collected before and after the swallowing exercises. The ability of the saliva to scavenge HO• and O2•− was measured using the X-band electron spin resonance spin trap method.Result：There was no significant inter-group difference between antioxidant values for resting saliva before and after the swallowing exercises, although there were large individual differences. It was further observed that group C had an increased O2•− antioxidant capacity, and an increased HO• antioxidant capacity, generated from the Fe2＋/H2O2 system. This was considered to be owing to the effects of aging or of general disease. In the comparison between saliva before and after swallowing exercises, the HO• scavenging ability of the saliva was significantly elevated after swallowing exercises compared with before swallowing exercises in group A, but not in groups B or C.The above results suggest that swallowing exercises can be used in group A for the activation of muscle function related to swallowing, and also to activate the defense mechanisms of the oral antioxidant system. However, there were no significant effects of swallowing exercises in groups B and C in this study. Thus, we would like to assess the antioxidant effects of adequate exercise, which is involved in the maintenance and improvement of swallowing/oral muscular functions, and the continuous effects of swallowing exercises in these groups.},
 school = {神奈川歯科大学},
 title = {嚥下体操がヒト唾液抗酸化能に及ぼす影響},
 year = {},
 yomi = {イチノセ, ショウタ}
}