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Blue Light from Dental Resin Curing Unit Causes Light-Induced Vasoconstriction in Isolated Rat Aorta
https://kdu.repo.nii.ac.jp/records/945
https://kdu.repo.nii.ac.jp/records/94596acd588-d75f-47ba-8635-49b5aa581db7
| 名前 / ファイル | ライセンス | アクション |
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論文内容要旨 (243.0 kB)
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論文審査要旨、最終審査の結果の要旨 (193.4 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-07-05 | |||||
| タイトル | ||||||
| タイトル | Blue Light from Dental Resin Curing Unit Causes Light-Induced Vasoconstriction in Isolated Rat Aorta | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Reactive oxygen species | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Dental curing lights | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Vasoconstriction | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Antioxidant | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | 歯科用レジン照射器による青色光は摘出ラット大動脈に対して光誘導性血管収縮を誘導す | |||||
| 言語 | ja | |||||
| 著者 |
岩田, 将
× 岩田, 将× Iwata, Sho |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aims: Currently, the blue light of resin curing unit is frequently used in dental treatment. However, the influence of the blue light irradiation on oral tissue is not lear. The aim of this study was to elucidate the effect of dental blue light irradiation on vascular smooth muscle. Methods: Isolated rat descending aorta was suspended in a superfusion chamber nd superfused continuously with Krebs-Ringer solution. The changes in isometric orce of blue light irradiation were assessed using vessel strips superfused with the Krebs-Ringer solution alone or the Krebs-Ringer solutions containing 10 µM hentolamine, 100 mM dimethyl sulfoxide, 10 unit/mL superoxide dismutase, or 5 M L-histidine. The reactive oxygen species (ROS) scavenging activity of antioxidants was examined using the electron spin resonance technique espectively. Results: We first demonstrated that the vasoconstriction was induced by irradiated of blue light using dental resin curing unit. The vasoconstriction was inhibited by ncluding in the Krebs-Ringer solution an α-receptor blocker that inhibits the eurotransmitter. This phenomenon was controlled with the addition of ROS cavengers. Conclusions: Blue light irradiation of multiple times in dental treatment might have the potential to accelerate aging of pulpal blood vessel from ischemia through dental pulp vasoconstriction via ROS generation. In addition, prolonged and/or repeated blue light irradiation could cause ROS-induced oxidative stress such as ischemia-reperfusion injury on pulpal blood vessel. Therefore, preintake of ntioxidants is suggested to avoid effects such as aging of dental pulp due to blue light irradiation-induced ROS in dental clinic treatments. |
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| 学位名 | ||||||
| 学位名 | 博士（臨床歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 32703 | |||||
| 学位授与機関名 | 神奈川歯科大学 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2015 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-03-17 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第479号 | |||||
| 情報源 | ||||||
| 関連名称 | Oral Health and Dental Management, 13(4):1147-1151, 2014. doi: 10.4172/2247-2452.1000745 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.omicsonline.org/archive/ohdm-volume-13-issue-4-year-2014.html | |||||
| 関連名称 | OMICS | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 見出し | ||||||
| 小見出し | PDF/A | |||||
| 言語 | ja | |||||
