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Reactive oxygen species scavenging activity of Jixueteng evaluated by electron spin resonance (ESR) and photon emission
https://kdu.repo.nii.ac.jp/records/27
https://kdu.repo.nii.ac.jp/records/27084c6ac9-5056-4e2b-85ea-66e3d411dbc3
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論文内容要旨 (176.4 kB)
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論文審査要旨、最終審査の結果の要旨 (193.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-04-14 | |||||
| タイトル | ||||||
| タイトル | Reactive oxygen species scavenging activity of Jixueteng evaluated by electron spin resonance (ESR) and photon emission | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Antioxidants | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Drugs, Chinese Herbal | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Electron Spin Resonance Spectroscopy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Luminescent Measurements | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Photons | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Reactive Oxygen Species | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | 電子スピン共鳴(ESR)法とXYZ化学発光法による鶏血藤の活性酸素消去活性の評価 | |||||
| 言語 | ja | |||||
| 著者 |
髙道, 麻臣
× 髙道, 麻臣× Takamichi, Maomi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Jixueteng, the dried stem of Spatholobus suberectus Dunn (Leguminosae), is a traditional Chinese herbal medicine that is commonly classified as a herb that promotes blood circulation and can be used to treat blood stasis. The aim of this study was to examine the reactive oxygen species (ROS) scavenging activity of Jixueteng and other herbal medicines. The ROS scavenging activities of the water extracts of Jixueteng, Cnidium officinale and Salvia miltiorrhiza were examined using an electron spin resonance (ESR) technique and faint luminescence measurement. The ESR signal intensities of the superoxide anion (O2·) and hydroxyl radical (HO·) were reduced more by Jixueteng than the other herbal medicines we tested. High photon emission intensity to hydrogen peroxide (H202) and HO· was observed in Jixueteng using the XYZ chemiluminescence system that was used as faint luminescence measurement and analysis. The results of the present study revealed that the ROS scavenging activity of 8% Jixueteng was the strongest among the herbal medicines we tested. It has been reported that Jixueteng includes various polyphenols. In the ROS scavenging activity by Jixueteng, it is supposed that the antioxidant activity caused by these polyphenols would contribute greatly. In conclusion, a water extract component of Jixueteng had potent free radical scavenging activity and an antioxidative effect that inhibited the oxidative actions of O2·⁻, H2O2 and HO·. Therefore, Jixueteng represents a promising therapeutic drug for reactive oxygen-associated pathologies. | |||||
| 学位名 | ||||||
| 学位名 | 博士（臨床歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 32703 | |||||
| 学位授与機関名 | 神奈川歯科大学 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2014 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-03-17 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第459号 | |||||
| 権利 | ||||||
| 権利情報 | This manuscript is final version prepared by the author(s), not the PDF file of the paper published in the Online Journal. Natural Product Communications (ISSN 1934-578X (printed); 1555-9475 (online)) The copyright of this paper belongs to the Natural Product Incorporation. ©2005 Natural Product Incorporation | |||||
| 情報源 | ||||||
| 関連名称 | Natural Product Communications, 9(12):1755-1759, 2014 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 見出し | ||||||
| 小見出し | PDF/A | |||||
| 言語 | ja | |||||
